The quiet machinery of life, rendered legibly.
Each entry pairs a photo-real three-dimensional structure with its catalytic cycle, its kinetic signature, and the vibrational modes that drive allostery. You can rotate, mutate, integrate — all in the browser, with the citations kept honest.
Mechanism, step by step
Curated catalytic cycles — key residues, transition states, rate-limiting steps — sourced from M-CSA and primary literature, not hand-waved.
Kinetics from the record
kcat, KM, kcat/KM, pH, temperature, and source for every entry, with a live RK4 integrator that lets you inhibit and observe.
Dynamics computed here
Upload any PDB and get normal modes, cross-correlations, and a steered elastic-network response in seconds — entirely in your browser.
Classic enzymes, chosen with care.
Each enzyme in the catalogue earns its place by pedagogical depth, structural clarity, and the availability of kinetic and mechanistic data — the ingredients needed to understand, not merely depict.
Lysozyme
The archetype of mechanistic enzymology. Cleaves β-1,4 glycosidic bonds in bacterial peptidoglycan through an oxocarbenium-ion intermediate.
TIM
A catalytically perfect enzyme — its reaction is limited only by diffusion. Interconverts GAP and DHAP via a cis-enediol(ate) intermediate.
Chymotrypsin
The paradigm of the catalytic triad (Ser-His-Asp). Two-step mechanism: acylation forms a covalent acyl-enzyme intermediate; deacylation by water releases the C-terminal product.
CA II
One of the fastest enzymes known (kcat ≈ 10⁶ s⁻¹). Catalyses the reversible hydration of CO₂ to bicarbonate via a zinc-hydroxide mechanism.
HIV-1 PR
Obligate homodimer where each subunit contributes one Asp25 to a shared catalytic dyad. Hydrolyses viral polyproteins into functional proteins — essential for HIV maturation.
Mpro
Cysteine-histidine catalytic dyad. Cleaves the coronaviral polyprotein at 11 conserved Leu-Gln↓(Ser/Ala/Gly) sites — essential for viral replication.